Gut health and longevity -
They paid particular attention to a longitudinal study of a community of over older adults to get a clearer picture of the makeup of the mature GI microbiome. The investigators found that older adults who had a more unique pattern of changes to their GI microbe profile also tended to be healthier and live longer than peers with less microbiome divergence.
One of these metabolites, tryptophan-derived-indole, has been shown to reduce inflammation and to extend lifespan in mouse studies. People whose gut microbiomes had grown more unique with age were able to walk faster and had better overall mobility than peers who showed less GI microbe changes with age.
Plus, those with less diverse gut environments used more medications and were nearly twice as likely to die during the study period. The research team suspects that modern diets rich in salty, sugary, or fatty processed foods may damage the aging gut, while higher fiber nutritious foods like fruits, vegetables, seeds, beans, and nuts could be combined with exercise to help protect a healthy gut microbiome balance as we age.
This research was supported in part by NIA grants U19AG, U01AG, U01AG, U01AG, AG, U01AG, U01AG and U01AG Reference: Wilmanski, Tomasz et al.
Gut microbiome pattern reflects healthy ageing and predicts survival in humans. Nature metabolism. An official website of the National Institutes of Health. Research Highlights Unique gut microbiome patterns linked to healthy aging, increased longevity May 13, gov An official website of the National Institutes of Health.
It was supported in part by a Catalyst Award in Healthy Longevity from the National Academy of Medicine, and the Longevity Consortium of the National Institute on Aging.
Materials provided by Institute for Systems Biology. Note: Content may be edited for style and length. Science News. Facebook Twitter Pinterest LinkedIN Email.
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Journal Reference : Tomasz Wilmanski, Christian Diener, Noa Rappaport, Sushmita Patwardhan, Jack Wiedrick, Jodi Lapidus, John C. Earls, Anat Zimmer, Gustavo Glusman, Max Robinson, James T.
Yurkovich, Deborah M. Kado, Jane A. Cauley, Joseph Zmuda, Nancy E. Lane, Andrew T. Magis, Jennifer C. Lovejoy, Leroy Hood, Sean M.
Gibbons, Eric S. Orwoll, Nathan D. Gut microbiome pattern reflects healthy ageing and predicts survival in humans. Nature Metabolism , Feb. Cite This Page : MLA APA Chicago Institute for Systems Biology. ScienceDaily, 18 February Institute for Systems Biology.
Gut microbiome implicated in healthy aging and longevity. Retrieved February 13, from www. htm accessed February 13, Explore More.
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BMC Ajd volume 22Article number: Cite this article. Hydration tips for reducing muscle soreness details. Longevity is gealth Bone health and hormones the most complex phenotypes, and its genetic basis healtu unclear. Gut health and longevity study aimed to explore the genetic correlation and potential causal association between gut microbiota and longevity. Linkage disequilibrium score LDSC regression analysis and a bi-directional two-sample Mendelian Randomization MR analysis were performed to analyze gut microbiota and longevity-related traits. Statistical insignificance of the heterogeneity test and pleiotropy test supported the validity of the MR study. Our study found evidence that gut microbiota is causally associated with longevity, or vice versa, providing novel clues for understanding the roles of gut microbiota in aging development.Gut health and longevity -
Probiotics and prebiotics, found in foods like yogurt, kefir, and sauerkraut, can also contribute to a flourishing gut microbiota. And right alongside a healthy diet sits exercise. Physical activity has been shown to positively influence the gut microbiota. Regular exercise helps maintain a diverse and balanced microbial community, contributing to overall health and longevity.
Chronic stress can negatively impact the gut microbiota, leading to imbalances. Practices such as meditation, deep breathing exercises, and mindfulness can help manage stress and support a healthy gut. While antibiotics are crucial for treating infections, their overuse can disrupt the balance of gut bacteria.
It's essential to use antibiotics judiciously and, when necessary, consider probiotic supplementation to restore the microbiome. As research into the intricate relationship between gut health and longevity continues, it becomes increasingly evident that nurturing your gut microbiome is key for healthy aging.
By adopting lifestyle choices that promote a diverse and balanced gut, you can enhance your overall well-being, potentially unlocking the secrets to a longer, healthier life.
So, let's embrace the power of a healthy gut and embark on a path to a vibrant and fulfilling future. Close Not ready to purchase? Stay in touch about special discounts, nutrition tips and additional education. The Digest. All Articles. How Gut Health Affects Longevity and Healthy Aging.
Here are some ways in which gut health may influence the aging process: Nutrient absorption and metabolism A healthy gut microbiome helps in the digestion and absorption of nutrients from food, ensuring that your body receives the necessary vitamins and minerals for proper functioning.
Inflammation Chronic, low-grade inflammation is associated with various age-related diseases. Brain health The gut-brain axis is a bidirectional communication system between the gut and the brain.
Metabolism and weight regulation Maintaining a diverse and healthy gut microbiome may positively influence your metabolism and weight regulation, which can contribute to overall health and longevity.
Synthesis of bioactive compounds Gut bacteria such as Anaerobutyricum hallii , Clostridium butyricum , and Clostridium beijerinckii can produce bioactive compounds such as short-chain fatty acids SCFAs , which have been associated with various health benefits.
Digestive health Maintaining a healthy gut microbiome is crucial for proper digestion and can help prevent issues such as constipation, diarrhea, and other gastrointestinal problems that can increase and impact the quality of life as you age.
Microbial diversity Aging is associated with a decrease in the diversity of the gut microbiota. Regular exercise And right alongside a healthy diet sits exercise. Stress management Chronic stress can negatively impact the gut microbiota, leading to imbalances.
Avoiding antibiotic overuse While antibiotics are crucial for treating infections, their overuse can disrupt the balance of gut bacteria. Sign up to receive healthy-living tips and exclusive offers. Studies show that healthy microbiome composition is key to human health.
Research also suggests that the gut microbiome plays a crucial role in the aging process. For example, studies show that the healthy centenarian gut microbiome is rich in bacteria that may promote healthy aging by warding off infections and inducing gut homeostasis.
Some studies show that viruses known as bacteriophages bind to bacteria in the gut, and affect their activity. In some cases, they may improve bacterial function by improving their metabolism. As centenarians have decreased susceptibility to age-related diseases and infections compared to younger individuals, understanding more about what makes their microbiomes unique could aid the development of strategies that promote healthy aging.
Recently, researchers compared the gut virome of Japanese centenarians with that of younger adults aged 18 years and over, and older adults aged 60 years and over. They found that centenarians had more diverse viromes than younger people in the study. The study was published in Nature.
Wes Ulm , a bioinformatic scientific resource analyst, and biomedical data specialist at the National Institutes of Health, not involved in the study, told Medical News Today :. And when this symbiosis is more effective, the body is able to greatly amplify its capacity to cleanse and renew itself.
More mechanistically-focused studies are currently in development. For the study, the researchers gathered stool sample data from Japanese and Sardinian studies, including centenarians, older adults, and 61 young adults. They used a virome discovery approach to identify viruses in the sample data.
Altogether, they identified 4, viruses, including 1, that were previously undescribed. After further analysis, they found that centenarians had more diverse gut bacteria and viromes than their younger counterparts. They also had higher levels of gut bacteria and viruses. High microbial diversity is usually associated with a healthy gut microbiome.
Infants tend to have high levels of actively replicating viruses that soon become dormant as they transition into adulthood. However, the researchers found that centenarians had higher levels of actively replicating viruses than younger adults — although not quite as many as infants.
The increased virome activity and diversity in centenarian microbiomes, noted the researchers, went on to boost the metabolic capacity of bacteria, which is linked to health benefits.
They noted, for example, that higher sulfur metabolism — as seen in the centenarians — is linked to increased protection against aerobic pathogens.
The viruses we found in the healthy Japanese centenarians contained extra genes that could boost the bacteria.
Ulm noted that a diverse gut virome enhances the detoxification functions of gut bacteria. Ulm noted that the findings demonstrate the relationship between the gastrointestinal tract and the human liver, which removes toxic metabolic byproducts from our bodies via a complex array of systems.
MNT also spoke with Dr. He noted that one limitation is that the study provided little information about what gave rise to the healthful microflora and viromes in the study. If we are able to get these bacteria and their viruses to move in with the people who do not have them, more people could benefit from them.
And the crazy thing is that we can actually change the composition of intestinal bacteria. We cannot change the genes — at least not for a long time to come. Should all viruses be considered villains?
In this feature, we meet bacteriophages.
Buettner is famously known for traveling all around the Bone health and hormones and Natural sports hydration five regions where people regularly live to be lonhevity in good health, logevity he ,ongevity Blue Gut health and longevity. Even heealth the Lonevity Zones span the globe, there are some diet and lifestyle habits they all have in common—including several that directly affect the gut. In Buettner's book he highlights six of them, which he elaborates on here. This is one gut check that just might add years to your life. Not surprisingly, many of the gut health habits on Buettner's list have to do with diet.
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