After the increased replavement Hormone replacement therapy in the first WHI results was reported inthe number of Prempro Hormone replacement therapy filled reduced Hormone replacement therapy almost half. Hrmone effectiveness of hormone replacement can decline in some women after long-term use. Women who have had higher stage and higher grade uterine tumours have a higher risk of the cancer coming back. Vaginal micronized progesterone may provide higher levels of endometrial progesterone exposure than oral progesterone. December Bruce D, Robinson J, McWilliams S, et al.

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