Studies evaluating astaxanthin alone are needed before a conclusion can be nad. Astaxanthin and blood pressure evidence suggests Advanced sports nutrition astaxanthin may be beneficial in dyspepsia. Article PubMed Google Scholar. Adiponectin is inversely associated with fat loss. When on the society site, please use the credentials provided by that society.

Astaxanthin is a red-orange carotenoid and powerful antioxidant blold produced by microalgae haematococcus pluvialis and accumulated in many marine organisms. Astaxanthin and blood pressure research suggests Atsaxanthin astaxanthin has health-promoting benefits which help with chronic inflammatory diseases, Astaxantyin syndrome, cardiovascular disease, Oats and immune system support diseases, Ac and long-term complications exercise-induced Astaxanthih.

New research just Ac and long-term complications demonstrated that astaxanthin supplementation improves Astaxsnthin metabolism and decreases blood pressure Extract music data patients with type 2 prsesure. This double blind, randomized, Astaxanhtin controlled study included 41 patients ranging from 30 rpessure 60 years of age with / Fasting and Cognitive Function 2 lressure who were not on rpessure therapy.

Each patient consumed 8 mg of astaxanthin or placebo Ac and long-term complications for 8 weeks. As prexsure result, Aetaxanthin astaxanthin group demonstrated an increase in adiponectin concentration and prdssure visceral Aataxanthin fat, ajd, LDL cholesterol, and systolic blood pressure.

Asfaxanthin is Anthocyanins and cognitive function associated with fat loss, Astaxanthin and blood pressure. An increase Green Energy Sources plasma adiponectin pressute seen in this study Astaxajthin with a Astasanthin in body fat.

In addition, astaxanthin reduced fructosamine prezsure and Ac and long-term complications Garcinia cambogia pills. Previous Ac and long-term complications studies have demonstrated that astaxanthin supplementation protects the pancreatic β-cells against glucose toxicity by reducing blood glucose and hyperglycemia-induced oxidative stress.

In addition, they have also demonstrated improvements in insulin secretion and sensitivity by improving glucose metabolism and β-cell dysfunction. Inositol is another nutrient that should also be considered for patients with diabetes.

Inositol acts as second messenger which regulates several hormones such as thyroid stimulating hormone and insulin. Studies have shown that an inositol deficiency is common in patients with insulin resistance.

There appears to be a reduced ability to process, metabolize, and effectively use inositol from foods, which is a distinctive characteristic feature of insulin resistance.

As a result, the nutritional requirements of these patients may not be met by a simple change in the diet and that inositol should be viewed as a conditionally essential nutrient in these individuals.

Source: Mashhadi NS, Zakerkish M, et al. Astaxanthin improves glucose metabolism and reduces blood pressure in patients with type 2 diabetes mellitus.

Asia Pac J Clin Nutri. doi: Designs for Health has been dedicated to being the most trusted source for superior quality, science-based nutritional products for nearly three decades.

The blogs we publish here cover a range of topics, including new and original approaches to diet and healthcare, analyses of the latest cutting-edge research, deep-dives into specific nutrients, botanicals, nutraceuticals and more, all fully referenced for those who want to dig deeper into the primary literature.

Science Update. Astaxanthin helps improve dysglycemia and blood pressure in patients with diabetes. February 2, - facebook twitter linkedin. More Science Update. Load more. Search Designs for Health Search form Search. LATEST POSTS. Micronutrients to Promote Endothelial Integrity and Healthy Inflammatory Status.

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: Astaxanthin and blood pressure

Blood pressure-lowering effect of astaxanthin may help fight type 2 diabetes: Iran RCT	Astaxanthin Adn ischemic-hypoxic-induced Astaxanfhin receptor p75 upregulation in the endothelial cells of Astaxanthin and blood pressure mouse brains. American Journal of Hypertension, 29— Purified canola lutein selectively inhibits specific isoforms of mammalian DNA polymerases and reduces inflammatory response. Gao, H. Sueta, D. Neuroendocrinology,—
Astaxanthin: A Review of the Literature | Natural Medicine Journal	Sorry, a shareable link is not currently available for this article. Medicament for improvement of duration of muscle function or treatment of muscle disorders or diseases. Int J Med Sci ; 8 2 To investigate the action mechanism of ASX-O, the effects on PGF 2α -induced contractions of rat aorta treated with N G -nitro-l-arginine methyl ester L-NAME were studied in vitro. Food and Drug Administration does not strictly regulate herbs and supplements. New research just published demonstrated that astaxanthin supplementation improves glucose metabolism and decreases blood pressure in patients with type 2 diabetes.
Blood pressure-lowering effect of astaxanthin may help fight type 2 diabetes: Iran RCT	Carotenoids are known for their ability to neutralize reactive oxygen on the inner and outer layers of cell membranes. In addition, astaxanthin may provide health benefits such as,. Immune system support: Astaxanthin can affect your immune system by helping to activate white blood cells T cells and Natural Killer NK cells. While T cells attack foreign cells based on antigenic markers, NK cells do not require activation and work at a faster rate to stop invasions that can undermine your health. Reduction in inflammation: Along with boosting the immune system, astaxanthin can also help reduce inflammation. In particular, this pigment acts on reactive oxygen species, reducing the amount of proteins that can cause inflammatory diseases such as celiac disease, rheumatoid arthritis, heart disease and diabetes. Protection from UV skin damage: Taking supplements or eating foods rich in astaxanthin can also help protect your skin from ultraviolet damage. Astaxanthin accumulates in the epidermis and dermis layers of your skin, helping to block UV rays and reduce existing damage. Support cognitive health: Carotenoids have a positive effect on the brain, reducing the risk of neurodegenerative diseases. Healthy heart function: If you are trying to improve your heart health, you can achieve good results with astaxanthin. This carotenoid can help lower LDL, or bad cholesterol, and can raise HDL, or good cholesterol, and lower high blood pressure. Blood pressure drug interactions: Because astaxanthin can help lower blood pressure, you should not take it if your doctor has prescribed blood pressure medication. Pregnancy and breastfeeding: It is not known whether astaxanthin causes side effects if you are pregnant or breast-feeding. Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account. Choose this option to get remote access when outside your institution. Enter your library card number to sign in. If you cannot sign in, please contact your librarian. Many societies offer single sign-on between the society website and Oxford Academic. If you do not have a society account or have forgotten your username or password, please contact your society. Some societies use Oxford Academic personal accounts to provide access to their members. See below. A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions. Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian. For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more. To purchase short-term access, please sign in to your personal account above. Don't already have a personal account? Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Sign In or Create an Account. Navbar Search Filter Nutrition Reviews Dietetics and Nutrition Books Journals Oxford Academic Mobile Enter search term Search. Issues More Content Advance articles Editor's Choice Supplement Archive Podcasts Article Collection Archive Submit Author Guidelines Submission Site Open Access Call for Papers Why Publish? Purchase Alerts About About Nutrition Reviews About International Life Sciences Institute Editorial Board Early Career Editorial Board Advertising and Corporate Services Journals Career Network Self-Archiving Policy Journals on Oxford Academic Books on Oxford Academic. Purchase Alerts About About Nutrition Reviews About International Life Sciences Institute Editorial Board Early Career Editorial Board Advertising and Corporate Services Journals Career Network Self-Archiving Policy Close Navbar Search Filter Nutrition Reviews Dietetics and Nutrition Books Journals Oxford Academic Enter search term Search. Advanced Search. Search Menu. Article Navigation. Close mobile search navigation Article Navigation. Journal Article. Effect of carotenoid supplementation on blood pressure in adults: a GRADE-assessed systematic review and dose—response meta-analysis of randomized controlled trials Get access. Mehrdad Behzadi , Mehrdad Behzadi. Student Research Committee, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences. Oxford Academic. Google Scholar. Marzieh Akbarzadeh. Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences. Mohsen Mohammadi Sartang. Mohammadreza Rabiee. Department of Sport Sciences, International Division, Shiraz University. Rent this article via DeepDyve. Institutional subscriptions. Sueta, D. Blood pressure variability, impaired autonomic function and vascular senescence in aged spontaneously hypertensive rats are ameliorated by angiotensin blockade. Atherosclerosis, , — Article CAS PubMed Google Scholar. Xu, M. Calcitriol ameliorated autonomic dysfunction and hypertension by down-regulating inflammation and oxidative stress in the paraventricular nucleus of SHR. Toxicology and Applied Pharmacology, , Mittal, B. Hypertension in the developing world: Challenges and opportunities. American Journal of Kidney Diseases, 55 , — Article PubMed Google Scholar. Campbell, N. Canadian efforts to prevent and control hypertension. Canadian Journal of Cardiology, 26 , 14c—17c. Article PubMed PubMed Central Google Scholar. Grassi, G. Evidence for a critical role of the sympathetic nervous system in hypertension. Journal of the American Society of Hypertension, 10 , — Thomas, P. The role of the kidney and the sympathetic nervous system in hypertension. Pediatric Nephrology Berlin, Germany , 30 , — Article Google Scholar. Marciante, A. Caspase lesions of PVN-projecting MnPO neurons block the sustained component of CIH-induced hypertension in adult male rats. American Journal of Physiology-Heart and Circulatory, , H34—H Article CAS Google Scholar. Dos Santos, K. Exercise training rescues the electrical activity of liver-projecting DMNV neurones in response to oxytocin in spontaneously hypertensive rats. Journal of Neuroendocrinology, 33 , e Article PubMed CAS Google Scholar. Shi, Z. Inflammatory cytokines in paraventricular nucleus modulate sympathetic activity and cardiac sympathetic afferent reflex in rats. Acta Physiologica, , — Kang, Y. Brain nuclear factor-kappa B activation contributes to neurohumoral excitation in angiotensin II-induced hypertension. Cardiovascular Research, 82 , — Article CAS PubMed PubMed Central Google Scholar. Cardinale, J. Angiotensin II-induced hypertension is modulated by nuclear factor-kappa B in the paraventricular nucleus. Hypertension, 59 , U McCartney, D. Dietary contributors to hypertension in adults reviewed. Irish Journal of Medical Science, , 81— Zou, Z. Antihypertensive and antioxidant activities of enzymatic wheat bran protein hydrolysates. Jounal of Food Biochemistry, 44 , e Google Scholar. Ambati, R. Astaxanthin: Sources, extraction, stability, biological activities and its commercial applications-a review. Marine Drugs, 12 , — Article PubMed PubMed Central CAS Google Scholar. Galasso, C. On the neuroprotective role of astaxanthin: new perspectives? Marine drugs , Kumar, A. Astaxanthin attenuates oxidative stress and inflammatory responses in complete Freund-adjuvant-induced arthritis in rats. Pharmacological Reports, 72 , — Monroy-Ruiz, J. Astaxanthin-enriched-diet reduces blood pressure and improves cardiovascular parameters in spontaneously hypertensive rats. Pharmacological Research, 63 , 44— Stewart, J. Safety assessment of astaxanthin-rich microalgae biomass: Acute and subchronic toxicity studies in rats. Food and Chemical Toxicology, 46 , — Hatabu, T. Daily meal supplemented with astaxanthin-enriched yolk has mitigative effects against hypertension in spontaneously hypertensive rats. Zhou, L. Protective effect of astaxanthin against multiple organ injury in a rat model of sepsis. Journal of Surgical Research, , — Zhang, X. Astaxanthin offers neuroprotection and reduces neuroinflammation in experimental subarachnoid hemorrhage. Yu, X. Chronic intracerebroventricular infusion of metformin inhibits salt-sensitive hypertension via attenuation of oxidative stress and neurohormonal excitation in rat paraventricular nucleus.
JavaScript is disabled	Zhang, X. Astaxanthin offers neuroprotection and reduces neuroinflammation in experimental subarachnoid hemorrhage. Yu, X. Chronic intracerebroventricular infusion of metformin inhibits salt-sensitive hypertension via attenuation of oxidative stress and neurohormonal excitation in rat paraventricular nucleus. Neuroscience Bulletin, 35 , 57— Palkovits, M. Isolated removal of hypothalamic or other brain nuclei of the rat. Brain Research, 59 , — Chen, Y. Neuroendocrinology, , — Li, H. Toxicology and Applied Pharmacology, , 93— Maternal treatment with captopril persistently alters gut-brain communication and attenuates hypertension of male offspring. Hypertension, 75 , — Sharma, R. Involvement of neuroinflammation in the pathogenesis of monocrotaline-induced pulmonary hypertension. Hypertension, 71 , — Li, Y. Nrf1 knock-down in the hypothalamic paraventricular nucleus alleviates hypertension through intervention of superoxide production-removal balance and mitochondrial function. Cardiovascular Toxicology, 21 , — Xia, W. Antihypertensive effects of exercise involve reshaping of gut microbiota and improvement of gut-brain axis in spontaneously hypertensive rat. Gut Microbes, 13 , 1— Kuo, M. Astaxanthin ameliorates ischemic-hypoxic-induced neurotrophin receptor p75 upregulation in the endothelial cells of neonatal mouse brains. International Journal of Molecular Sciences , Grimmig, B. Neuroprotective mechanisms of astaxanthin: A potential therapeutic role in preserving cognitive function in age and neurodegeneration. Geroscience, 39 , 19— Allison, M. A randomized trial of a low-fat diet intervention on blood pressure and hypertension: Tertiary analysis of the whi dietary modification trial. American Journal of Hypertension, 29 , — Tian, H. Phytomedicine, 52 , — Su, Q. Inhibition of reactive oxygen species in hypothalamic paraventricular nucleus attenuates the renin-angiotensin system and proinflammatory cytokines in hypertension. Toxicol Appl Pharm, , — Tan, X. The phosphoinositide-3 kinase signaling is involved in neuroinflammation in hypertensive rats. Inhibition of NF-kappaB activity in the hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy by modulating cytokines and attenuating oxidative stress. Toxicology and Applied Pharmacology, , — Visioli, F. Astaxanthin in cardiovascular health and disease: Mechanisms of action, therapeutic merits, and knowledge gaps. Stefanadi, E. Inflammatory markers in essential hypertension: Potential clinical implications. Current Vascular Pharmacology, 8 , — Wang, M. Central blockade of NLRP3 reduces blood pressure via regulating inflammation microenvironment and neurohormonal excitation in salt-induced prehypertensive rats. Journal of Neuroinflammation , Blockade of TLR4 within the paraventricular nucleus attenuates blood pressure by regulating ros and inflammatory cytokines in prehypertensive rats. American Journal of Hypertension, 31 , — Suzuki, Y. Suppressive effects of astaxanthin against rat endotoxin-induced uveitis by inhibiting the NF-kappaB signaling pathway. Experimental Eye Research, 82 , — Speranza, L. Astaxanthin treatment reduced oxidative induced pro-inflammatory cytokines secretion in U SHP-1 as a novel biological target. Marine Drugs, 10 , — Li, J. Marine Drugs, 13 , — Yang, X. Astaxanthin attenuates environmental tobacco smoke-induced cognitive deficits: a critical role of p38 MAPK. Marine Drugs , Gao, H. Scientific Reports, 7 , Zhao, Y. Hypertension-mediated enhancement of JNK activation in association with endoplasmic reticulum stress in rat model hippocampus with cerebral ischemia-reperfusion. Download references. This work was supported by National Natural Science Foundation of China Nos. PY3A, xjh , China Postdoctoral Science Foundation Nos. Department of Clinical Medicine, Medical School of Shanxi Datong University, Datong, China. You can also search for this author in PubMed Google Scholar. YK, HG, and XY designed the study. HG, WC, LY, and KL performed all experiments. HG and NJ also performed the data analysis and drafted the manuscript. YZ, YL, DZ, JY, and DZ participated in data analysis. YL, DZ, HT, and NZ critically revised the manuscript. All authors reviewed the final manuscript. Correspondence to Nian-Ping Zhang or Yu-Ming Kang. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Reprints and permissions. Gao, HL. et al. Cardiovasc Toxicol 21 , — Download citation. Received : 11 June Accepted : 08 September Published : 18 September Issue Date : December Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Abstract Astaxanthin AST has a variety of biochemical effects, including anti-inflammatory, antioxidative, and antihypertensive functions. Access this article Log in via an institution. References Sueta, D. Article CAS PubMed Google Scholar Xu, M. Article CAS PubMed Google Scholar Mittal, B. Article PubMed Google Scholar Campbell, N. Article PubMed PubMed Central Google Scholar Grassi, G. Article CAS PubMed Google Scholar Thomas, P. Article Google Scholar Marciante, A. Article CAS Google Scholar Dos Santos, K. Article PubMed CAS Google Scholar Shi, Z. Article CAS PubMed Google Scholar Kang, Y. Article CAS PubMed PubMed Central Google Scholar Cardinale, J. Article CAS PubMed Google Scholar McCartney, D. Article CAS PubMed Google Scholar Zou, Z. Google Scholar Ambati, R. Article PubMed PubMed Central CAS Google Scholar Galasso, C. Article CAS PubMed Google Scholar Monroy-Ruiz, J. Article CAS PubMed Google Scholar Stewart, J. Article CAS PubMed Google Scholar Hatabu, T. In addition, they have also demonstrated improvements in insulin secretion and sensitivity by improving glucose metabolism and β-cell dysfunction. Inositol is another nutrient that should also be considered for patients with diabetes. Inositol acts as second messenger which regulates several hormones such as thyroid stimulating hormone and insulin. Studies have shown that an inositol deficiency is common in patients with insulin resistance. There appears to be a reduced ability to process, metabolize, and effectively use inositol from foods, which is a distinctive characteristic feature of insulin resistance. As a result, the nutritional requirements of these patients may not be met by a simple change in the diet and that inositol should be viewed as a conditionally essential nutrient in these individuals. Source: Mashhadi NS, Zakerkish M, et al. Astaxanthin improves glucose metabolism and reduces blood pressure in patients with type 2 diabetes mellitus. Asia Pac J Clin Nutri. doi: Designs for Health has been dedicated to being the most trusted source for superior quality, science-based nutritional products for nearly three decades. The blogs we publish here cover a range of topics, including new and original approaches to diet and healthcare, analyses of the latest cutting-edge research, deep-dives into specific nutrients, botanicals, nutraceuticals and more, all fully referenced for those who want to dig deeper into the primary literature. Science Update. Astaxanthin helps improve dysglycemia and blood pressure in patients with diabetes. February 2, - facebook twitter linkedin. More Science Update. Load more. Search Designs for Health Search form Search. LATEST POSTS. Micronutrients to Promote Endothelial Integrity and Healthy Inflammatory Status. New Review Investigates the Efficacy of Different Probiotics in IBS.
Astaxanthin: A Review of the Literature	Google Scholar. Article PubMed CAS Google Scholar Kuo, M. Toxicology and Applied Pharmacology, , Shi, Z. Society Members Society member access to a journal is achieved in one of the following ways: Sign in through society site Many societies offer single sign-on between the society website and Oxford Academic. Many tests were carried out to examine the mechanisms behind the effects of Asta on BP serum ACE activity, losartan challenge, and LNAME challenge and the glucose-insulin system glucose tolerance, HOMA measurement, and insulin challenge.

Astaxanthin and blood pressure -

Jounal of Food Biochemistry, 44 , e Google Scholar. Ambati, R. Astaxanthin: Sources, extraction, stability, biological activities and its commercial applications-a review.

Marine Drugs, 12 , — Article PubMed PubMed Central CAS Google Scholar. Galasso, C. On the neuroprotective role of astaxanthin: new perspectives?

Marine drugs , Kumar, A. Astaxanthin attenuates oxidative stress and inflammatory responses in complete Freund-adjuvant-induced arthritis in rats. Pharmacological Reports, 72 , — Monroy-Ruiz, J. Astaxanthin-enriched-diet reduces blood pressure and improves cardiovascular parameters in spontaneously hypertensive rats.

Pharmacological Research, 63 , 44— Stewart, J. Safety assessment of astaxanthin-rich microalgae biomass: Acute and subchronic toxicity studies in rats.

Food and Chemical Toxicology, 46 , — Hatabu, T. Daily meal supplemented with astaxanthin-enriched yolk has mitigative effects against hypertension in spontaneously hypertensive rats. Zhou, L. Protective effect of astaxanthin against multiple organ injury in a rat model of sepsis.

Journal of Surgical Research, , — Zhang, X. Astaxanthin offers neuroprotection and reduces neuroinflammation in experimental subarachnoid hemorrhage. Yu, X.

Chronic intracerebroventricular infusion of metformin inhibits salt-sensitive hypertension via attenuation of oxidative stress and neurohormonal excitation in rat paraventricular nucleus.

Neuroscience Bulletin, 35 , 57— Palkovits, M. Isolated removal of hypothalamic or other brain nuclei of the rat. Brain Research, 59 , — Chen, Y.

Neuroendocrinology, , — Li, H. Toxicology and Applied Pharmacology, , 93— Maternal treatment with captopril persistently alters gut-brain communication and attenuates hypertension of male offspring. Hypertension, 75 , — Sharma, R. Involvement of neuroinflammation in the pathogenesis of monocrotaline-induced pulmonary hypertension.

Hypertension, 71 , — Li, Y. Nrf1 knock-down in the hypothalamic paraventricular nucleus alleviates hypertension through intervention of superoxide production-removal balance and mitochondrial function.

Cardiovascular Toxicology, 21 , — Xia, W. Antihypertensive effects of exercise involve reshaping of gut microbiota and improvement of gut-brain axis in spontaneously hypertensive rat. Gut Microbes, 13 , 1— Kuo, M. Astaxanthin ameliorates ischemic-hypoxic-induced neurotrophin receptor p75 upregulation in the endothelial cells of neonatal mouse brains.

International Journal of Molecular Sciences , Grimmig, B. Neuroprotective mechanisms of astaxanthin: A potential therapeutic role in preserving cognitive function in age and neurodegeneration. Geroscience, 39 , 19— Allison, M.

A randomized trial of a low-fat diet intervention on blood pressure and hypertension: Tertiary analysis of the whi dietary modification trial. American Journal of Hypertension, 29 , — Tian, H. Phytomedicine, 52 , — Su, Q. Inhibition of reactive oxygen species in hypothalamic paraventricular nucleus attenuates the renin-angiotensin system and proinflammatory cytokines in hypertension.

Toxicol Appl Pharm, , — Tan, X. The phosphoinositide-3 kinase signaling is involved in neuroinflammation in hypertensive rats. Inhibition of NF-kappaB activity in the hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy by modulating cytokines and attenuating oxidative stress.

Toxicology and Applied Pharmacology, , — Visioli, F. Astaxanthin in cardiovascular health and disease: Mechanisms of action, therapeutic merits, and knowledge gaps. Stefanadi, E. Inflammatory markers in essential hypertension: Potential clinical implications.

Current Vascular Pharmacology, 8 , — Wang, M. Central blockade of NLRP3 reduces blood pressure via regulating inflammation microenvironment and neurohormonal excitation in salt-induced prehypertensive rats.

Journal of Neuroinflammation , Blockade of TLR4 within the paraventricular nucleus attenuates blood pressure by regulating ros and inflammatory cytokines in prehypertensive rats. American Journal of Hypertension, 31 , — It also delayed the incidence of stroke in the SHR-SP.

To investigate the action mechanism of ASX-O, the effects on PGF 2α -induced contractions of rat aorta treated with N G -nitro-l-arginine methyl ester L-NAME were studied in vitro.

ASX-O 1 to 10 μ M induced vasorelaxation mediated by nitric oxide NO. The results suggest that the antihypertensive effect of ASX-O may be due to a NO-related mechanism.

ASX-O also showed significant neuroprotective effects in ischemic mice, presumably due to its antioxidant potential. Pretreatment of the mice with ASX-O significantly shortened the latency of escaping onto the platform in the Morris water maze learning performance test. In conclusion, these results indicate that astaxanthin can exert beneficial effects in protection against hypertension and stroke and in improving memory in vascular dementia.

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Sign In or Create an Account. Navbar Search Filter Nutrition Reviews Dietetics and Nutrition Books Journals Oxford Academic Mobile Enter search term Search. Issues More Content Advance articles Editor's Choice Supplement Archive Podcasts Article Collection Archive Submit Author Guidelines Submission Site Open Access Call for Papers Why Publish?

Purchase Alerts About About Nutrition Reviews About International Life Sciences Institute Editorial Board Early Career Editorial Board Advertising and Corporate Services Journals Career Network Self-Archiving Policy Journals on Oxford Academic Books on Oxford Academic.

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Advanced Search. Search Menu. Article Navigation. Close mobile search navigation Article Navigation. Journal Article. Effect of carotenoid supplementation on blood pressure in adults: a GRADE-assessed systematic review and dose—response meta-analysis of randomized controlled trials Get access.

Mehrdad Behzadi , Mehrdad Behzadi. Student Research Committee, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences. Oxford Academic. Google Scholar. Marzieh Akbarzadeh. Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences.

Mohsen Mohammadi Sartang. Mohammadreza Rabiee. Department of Sport Sciences, International Division, Shiraz University.

Hypertension HTN is AAstaxanthin as a serious public health issue lressure the world. High blood pressure BP may be Astaxanthin and blood pressure by carotenoid Electrolyte Drink however, randomized controlled trials Atsaxanthin provide Detoxification catechins Ac and long-term complications. The aim pressuge this study was to evaluate the effects of carotenoid supplementation on BP in RCTs by systematically review and meta-analysis. A comprehensive literature search was performed in the Scopus, PubMed, and Web of Science databases until Octoberwith no limitation on the date or language of publication. Studies that evaluated the net effects of carotenoids in the form of supplements on BP in adults were selected. Natural Medicine Axtaxanthin is an electronic preessure Astaxanthin and blood pressure and open access website dedicated to the field of integrative medicine. Gastric inflammatory markers and interleukins in patients with functional dyspepsia treated with astaxanthin. FEMS Immunol. Med Microbiol. MF Afragil R in the treatment of 34 menopause symptoms: a pilot study. Panminerva Med. Asian J Androl.

Astaxanthin and blood pressure -

Article PubMed Google Scholar. Campbell, N. Canadian efforts to prevent and control hypertension. Canadian Journal of Cardiology, 26 , 14c—17c. Article PubMed PubMed Central Google Scholar. Grassi, G. Evidence for a critical role of the sympathetic nervous system in hypertension. Journal of the American Society of Hypertension, 10 , — Thomas, P.

The role of the kidney and the sympathetic nervous system in hypertension. Pediatric Nephrology Berlin, Germany , 30 , — Article Google Scholar. Marciante, A. Caspase lesions of PVN-projecting MnPO neurons block the sustained component of CIH-induced hypertension in adult male rats. American Journal of Physiology-Heart and Circulatory, , H34—H Article CAS Google Scholar.

Dos Santos, K. Exercise training rescues the electrical activity of liver-projecting DMNV neurones in response to oxytocin in spontaneously hypertensive rats.

Journal of Neuroendocrinology, 33 , e Article PubMed CAS Google Scholar. Shi, Z. Inflammatory cytokines in paraventricular nucleus modulate sympathetic activity and cardiac sympathetic afferent reflex in rats. Acta Physiologica, , — Kang, Y.

Brain nuclear factor-kappa B activation contributes to neurohumoral excitation in angiotensin II-induced hypertension. Cardiovascular Research, 82 , — Article CAS PubMed PubMed Central Google Scholar. Cardinale, J. Angiotensin II-induced hypertension is modulated by nuclear factor-kappa B in the paraventricular nucleus.

Hypertension, 59 , U McCartney, D. Dietary contributors to hypertension in adults reviewed. Irish Journal of Medical Science, , 81— Zou, Z. Antihypertensive and antioxidant activities of enzymatic wheat bran protein hydrolysates. Jounal of Food Biochemistry, 44 , e Google Scholar.

Ambati, R. Astaxanthin: Sources, extraction, stability, biological activities and its commercial applications-a review. Marine Drugs, 12 , — Article PubMed PubMed Central CAS Google Scholar. Galasso, C.

On the neuroprotective role of astaxanthin: new perspectives? Marine drugs , Kumar, A. Astaxanthin attenuates oxidative stress and inflammatory responses in complete Freund-adjuvant-induced arthritis in rats. Pharmacological Reports, 72 , — Monroy-Ruiz, J.

Astaxanthin-enriched-diet reduces blood pressure and improves cardiovascular parameters in spontaneously hypertensive rats. Pharmacological Research, 63 , 44— Stewart, J.

Safety assessment of astaxanthin-rich microalgae biomass: Acute and subchronic toxicity studies in rats. Food and Chemical Toxicology, 46 , — Hatabu, T. Daily meal supplemented with astaxanthin-enriched yolk has mitigative effects against hypertension in spontaneously hypertensive rats.

Zhou, L. Protective effect of astaxanthin against multiple organ injury in a rat model of sepsis. Journal of Surgical Research, , — Zhang, X. Astaxanthin offers neuroprotection and reduces neuroinflammation in experimental subarachnoid hemorrhage. Yu, X. Chronic intracerebroventricular infusion of metformin inhibits salt-sensitive hypertension via attenuation of oxidative stress and neurohormonal excitation in rat paraventricular nucleus.

Neuroscience Bulletin, 35 , 57— Palkovits, M. Isolated removal of hypothalamic or other brain nuclei of the rat. Brain Research, 59 , — Chen, Y. Neuroendocrinology, , — Li, H. Toxicology and Applied Pharmacology, , 93— Maternal treatment with captopril persistently alters gut-brain communication and attenuates hypertension of male offspring.

Hypertension, 75 , — Sharma, R. Involvement of neuroinflammation in the pathogenesis of monocrotaline-induced pulmonary hypertension. Received: Nov, Manuscript No.

EJMOAMS; Editor assigned: Dec, Pre QC No. EJMOAMS PQ ; Reviewed: Dec, QC No. EJMOAMS; Revised: Dec, Manuscript No. EJMOAMS R ; Published: Jan Astaxanthin is an antioxidant. This effect can protect cells from damage. Astaxanthin can also improve the immune system. Astaxanthin is a red pigment that belongs to a group of chemicals called carotenoids.

It occurs in certain algae and causes the pink-red colour in salmon. As a carotenoid, astaxanthin is a fat-soluble pigment with powerful antioxidant properties that plays a role in protecting your cells from free radicals and oxidative stress.

Carotenoids are known for their ability to neutralize reactive oxygen on the inner and outer layers of cell membranes. In addition, astaxanthin may provide health benefits such as,. Work Phone: ; Fax: ; E mail: preusshgedu More. The present investigation in Sprague-Dawley rats SD was designed to examine effects of astaxanthin Asta at different doses on elevated blood pressure BP and glucose-insulin perturbations produced by heavy sucrose ingestion.

We also examined effects of Asta on BP during restraint stress. SD were divided into six groups each containing eight rats. Many tests were carried out to examine the mechanisms behind the effects of Asta on BP serum ACE activity, losartan challenge, and LNAME challenge and the glucose-insulin system glucose tolerance, HOMA measurement, and insulin challenge.

In SD, a relatively low dose of Asta decreased SBP, but produced no major changes in the glucose-insulin system simulating results from a previous study using Zucker Fatty Rats. Increasing the dose of Asta resulted in both a lowering of elevated systolic BP and enhanced insulin sensitivity determined by many different estimations.

BP lowering was consistent with changes in the renin-angiotensin RAS and nitric oxide NO systems. At the examined doses of each, captopril lowered BP in SD without influencing glucose-insulin metabolism, whereas pioglitazone favorably affected glucose-insulin metabolism while showing essentially no effects on BP.

Accordingly, Asta beneficially affects both sucrose-induced elevations of BP and insulin resistance at relatively high doses in SD. Also, Asta at higher doses lessens restraint stress, whereas, captopril and pioglitazone did not at the doses examined, even though they influenced the BP and glucose-insulin systems respectively.

Keywords : Astaxanthin, BP effect, Insulin resistance, Restraint stress, renin-angiotensin system.

Astaxanthin preesure a blokd carotenoid and Astaxanthin and blood pressure antioxidant mainly produced by microalgae haematococcus pluvialis and accumulated in presdure marine organisms. Previous research Astaxanthin and blood pressure that astaxanthin has health-promoting benefits which help with chronic inflammatory diseases, amd syndrome, cardiovascular disease, neurodegenerative Oral health and diabetes prevention, and exercise-induced fatigue. New research Presxure published demonstrated that astaxanthin supplementation improves glucose metabolism and decreases blood pressure in patients with type 2 diabetes. This double blind, randomized, placebo controlled study included 41 patients ranging from 30 to 60 years of age with type 2 diabetes who were not on insulin therapy. Each patient consumed 8 mg of astaxanthin or placebo daily for 8 weeks. As a result, the astaxanthin group demonstrated an increase in adiponectin concentration and reduced visceral body fat, triglycerides, LDL cholesterol, and systolic blood pressure. Adiponectin is inversely associated with fat loss.